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KMID : 1151820120060020099
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Journal of the Korean Society of Radiology
2012 Volume.6 No. 2 p.99 ~ p.106
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The Effect of glutathione contents of White Ginseng(WG) Extracts and Entomopathogenic Fugi Extracts on the liver in Mice that was irradiated by radiation
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Ko In-Ho
Yoe Jin-Dong
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Abstract
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The radioprotective effects of white ginseng and Entomopathogenic Fugi Extract on liver damage induced by X-ray were investigated. To one group of ICR male mice were given white ginseng(150 mg/kg/day for 7days, orally) and Entomopathogenic Fugi (200 mg/kg/day for 7days, orally) before X-ray irradiation. To another group were irradiated by 5 Gy(1.01 Gy/min) dose of X-ray. Contrast group were given with saline(0.1 ml). The levels of reduced(GSH) and oxidized(GSSG) glutathione in liver tissue were measured. The ratio of GSSG/total GSH was significantly decreased in the white ginseng and Entomopathogenic Fugi (200 mg/kg/day)(150 mg/kg/day) groups than irradiation group.
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KEYWORD
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X-ray, GSH, GSSG, Entomopathogenic Fugi, white ginseng, EF+Rad
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